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GKT136901 hydrochloride
CAS No. 1254507-01-1
GKT136901 hydrochloride( —— )
Catalog No. M35054 CAS No. 1254507-01-1
GKT136901 hydrochloride is a NOX-1/4 inhibitor, a selective scavenger of peroxynitrite, which inhibits METH-induced ROS production.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 37 | Get Quote |
|
| 10MG | 69 | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameGKT136901 hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionGKT136901 hydrochloride is a NOX-1/4 inhibitor, a selective scavenger of peroxynitrite, which inhibits METH-induced ROS production.
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DescriptionGKT136901 hydrochloride is a potent, selective and orally active inhibitor of NADPH oxidase (NOX1/4), with Kis of 160 and 165 nM, respectively. GKT136901 hydrochloride is also a selective and direct scavenger of peroxynitrite. GKT136901 hydrochloride can be used for the research of diabetic nephropathy, stroke, and neurodegeneration. GKT136901 hydrochloride also has anti-inflammatory activity.
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In Vitro——
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In VivoAnimal Model:Male db/db and db/m mice (8 weeks)Dosage:30, 90 mg/kg Administration:Daily p.o. for 16 weeksResult:Reduced albuminuria, thiobarbituric acid-reacting substances (TBARS) and renal ERK1/2 phosphorylation and preserved renal structure in diabetic mice.Had no effect on plasma glucose, BP (blood pressure), and body weight.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetNADPH
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RecptorNADPH-oxidase
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Research Area——
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Indication——
Chemical Information
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CAS Number1254507-01-1
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Formula Weight403.26
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Molecular FormulaC19H16Cl2N4O2
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 62.5 mg/mL (154.99 mM; Ultrasonic ) H2O : 4 mg/mL (9.92 mM; Ultrasonic (<60°C))
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SMILESCl.O=C1C=C2NN(C(=O)C2=C(N1CC3=NC=CC=C3)C)C=4C=CC=CC4Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Laleu B, et, al. First in class, potent, and orally bioavailable NADPH oxidase isoform 4 (Nox4) inhibitors for the treatment of idiopathic pulmonary fibrosis. J Med Chem. 2010 Nov 11;53(21):7715-30.?
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